What Causes the Denaturation of Proteins. Denaturation is a process in which proteins or nucleic acids lose the quaternary structure tertiary structure and secondary structure which is present in their native state by application of some external stress or compound such as a strong acid or base a concentrated inorganic salt an organic solvent agitation and radiation or heat. Denaturation An Overview Sciencedirect Topics Denaturing a protein is occasionally irreversible Top The protein albumin in raw and cooked egg white. . This is why a protein such as. Celiac disease is a disorder characterized by autoimmune reactions in response to consumption of _____. The proteins in eggs denature and coagulate during cooking. The process of protein denaturation strictly refers to the breakdown of non-covalent interactions which maintain the secondary tertiary and quaternary structure of a protein. However denaturation can be irreversi